Aspirin: still learning about the wonder drug
نویسندگان
چکیده
منابع مشابه
Mechanistic Insights into a Classic Wonder Drug—Aspirin
Aspirin, one of the oldest and most common anti-inflammatory agents, has recently been shown to reduce cancer risks. The principal pharmacological effects of aspirin are known to arise from its covalent modification of cyclooxygenase-2 (COX-2) through acetylation of Ser530, but the detailed mechanism of its biochemical action and specificity remains to be elucidated. In this work, we have fille...
متن کاملDrug resistance: still on the learning curve.
For oncologists, the identification of the transporter MDR1/Pgp as a mechanism of drug resistance offered the possibility of finally succeeding in the treatment of patients with refractory tumors. Numerous laboratory studies in cell line models have shown that high levels of MDR1/Pgp can confer resistance levels of 1000-fold or more. These cell lines could be dramatically sensitized to chemothe...
متن کاملThe Wonder Approach to learning
Wonder, innate in the child, is an inner desire to learn that awaits reality in order to be awakened. Wonder is at the origin of reality-based consciousness, thus of learning. The scope of wonder, which occurs at a metaphysical level, is greater than that of curiosity. Unfortunate misinterpretations of neuroscience have led to false brain-based ideas in the field of education, all of these base...
متن کاملPenicillin: The Old/New Wonder Drug
Although it was discovered in 1928 by Alexander Fleming, a microbiologist at St. Mary’s Hospital in London, penicillin languished for more than a decade before its importance was noticed. As its antimicrobial properties became more apparent, large enough quantities were produced for clinical trials through the efforts of Florey et al. [1]. Then came World War II, and the U.S. government became ...
متن کاملthe relationship between locus of control and iranian efl university students’ beliefs about language learning
this exploratory study aimed to investigate a possible relationship between learners’ beliefs about language learning and one of their personality traits; that is,locus of control (loc). both variables, beliefs and locus of control, are assumed to influence the language learning process. the internal control index (ici) and the beliefs about language learning inventory (balli) were administered...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 2003
ISSN: 0017-5749
DOI: 10.1136/gut.52.11.1535